The most senior body of Pro Helvetia is the Board of Trustees. Its currently 25 members are appointed by the Federal Council. Pro Helvetia is domiciled in Berne. Its Head Office is located in Zurich.

In 2010 the Arts Council staff comprised the equivalent of 56 full-time positions. Outside Switzerland Pro Helvetia maintains four liaison offices: in Cairo, Warsaw, Cape Town and India.

It runs the cultural centre in Paris and is the principal financial backer of the Istituto Svizzero di Roma (cultural section) and the Swiss Institute in New York. The employees abroad share a total of 19 full-time posts.